Take your time with it. When I do play it I usually just spend my time devoting a whole day to setting up the season. Tactics training signings etc. Once done I just put it in the back ground when I am on the PC and let it run on Autopilot. Check in every month or two and tweak whatever is necessary and let her run again.
If you ****ed around with the settings for every game it would take nearly 1 months playing every day to get through a season!!!